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Once in the CNS, these peripherally activated CD4 T cells support the maturation and functional regulation of brain-resident microglia [114]

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This regulatory mechanism explains the so-called arginine paradox, which refers to the phenomenon where extracellular L-arginine availability influences NO production despite the saturation of NOS enzymes with intracellular arginine

doi: 10.1038/s41419-024-06456-5 145 WeiXYangZReyFERidauraVKDavidsonNOGordonJIet al