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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Lee Y.S., Park M.S., Choung J.S., Kim S.S., Oh H.H., Choi C.S., Ha S.Y., Kang Y., Kim Y., Jun H.S

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The disruption extends beyond direct receptor binding-EED exposure significantly impairs recruitment of critical coactivators such as steroid receptor coactivator-1 (SRC-1), substantially weakening AR transcriptional capacity (35)

Polyphenols can suppress the expression and activity of key pro-inflammatory mediators, such as nuclear factor-B (NF-B), a transcription factor vital to the regulation of the inflammatory response, as shown in Table 2 (269, 270)

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Additional oncology applications include cancer-related fatigue, post-radiation recovery, and general immune system support during treatment