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The reduced enzymatic activity increases cellular concentrations of both substrates that NNMT would otherwise consume: S-adenosyl-L-methionine (the universal cellular methyl donor) and nicotinamide (the NAD + salvage precursor)

Since B vitamins are water-soluble and easily depleted by stress, illness, diet, or certain medications, many people become deficient without realising it

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Eating animal products typically gives your body more than enough of the nutrient, but there are particular groups of people more susceptible to a B12 deficiency