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If you have had positive experiences with B12 injections in the past or if you are interested in NAD+ for longevity reasons, your provider will consider that input

For someone carrying enough weight to be facing serious metabolic risk such as type 2 diabetes, cardiovascular disease, joint failure etc, the trade-off likely makes sense

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Detailed patient information can be found here.

[8] [9] It is important to note that this evidence relates specifically to people with type 2 diabetes and CKD