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408 Multiple evaluations and analyses have shown that rTMS can effectively treat MDD in patients from different age groups, including children and adolescents, 409,410 adults, 411,412 and elderly patients

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The safety data available derive from Phase 2 clinical trials (Jastreboff et al., NEJM, 2023), which, whilst informative, represent a relatively limited population and duration of follow-up compared to post-marketing surveillance

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Participants were assigned in a 3:1 ratio to receive once-weekly CagriSema (2.4 mg each of cagrilintide and semaglutide) or placebo for 68 weeks, alongside standardised lifestyle interventions

There are now dozens of clinical trials underway to explore what other diseases they could treat