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Clinical criteria that must be documented for approval of a PA request for lipotropics, PCSK9 inhibitor drugs for members with HeFH are all of the following: Note: For PA requests for non-preferred lipotropics, PCSK9 inhibitor drugs, the member must have taken a preferred lipotropics, PCSK9 inhibitor drug concurrently with a maximized statin regimen (if tolerant) for at least three continuous months with failure to reach an LDL less than or equal to 100 mg/dL

Aim for at least 2 to 2.5 litres daily, but increase this amount if you are exercising, sweating more, or experiencing side effects like vomiting or constipation