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Support for this comes from the expression of VgR and HSP70

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In parallel, LPS and inflammation perturb hepatic clock gene expression and time-of-day responses (for example altering Per and, in specific contexts, BMAL1 expression), which further deranges metabolic rhythmicity and amplifies vulnerability to steatotic progression

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For the full breakdown, see our TRANSCEND-T2D-1 results guide