glutathione and mitochondrial function GSH Mitochondria function and redox biology.

In contrast, COX-1 is normally active in many tissues, where it has roles unrelated to inflammation (e.g., clotting function in blood platelets, mucus production from cells lining the GI tract) (Toussaint 2010

doi: 10.1002/hep.510270418

N-methylation decreases enzymatic degradation and increases intestinal epithelium transport

143 Jiang et al

Personally, I know through genetic testing that I have the SNP (single nucleotide polymorphism) rs1050450(C;T) on my GPX1 gene which reduces my glutathione peroxidase activity and therefore my ability to combat oxidative stress

Tachyphylaxis Rapid Exhaustion of the Readily Releasable Pool : The primary neurobiological mechanism driving acute stimulant tolerance is the rapid exhaustion of the readily releasable pool (RRP) of synaptic vesicles (Kaeser and Regehr, 2017