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Amidation involves conversion of the C-terminal carboxyl group (COO) to a neutral amide (CONH)

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Patients should avoid ingesting large amounts of vitamin C within 1 hour of oral vitamin B12 administration Extended release potassium products Antibiotics such as gentamicin, neomycin, tobramycin Anti-seizure medications such as phenobarbital, phenytoin, primidone Medicines used to treat heartburn like H2 blockers such as cimetidine and proton pump inhibitors such as omeprazole Antacids such as ranitidine, cimetidine Vitamin B12 Injection Storage and Safety Information Vitamin B12 tablets should be in a cool and dry place

If they are not accepted, they will be brought to a post office or depot and most likely will not be stored in a refrigerated area

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