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Mitochondrial permeability disrupts the ion gradients across the inner mitochondrial membrane, resulting in mitochondrial depolarization, a loss of oxidative phosphorylation, and an increase in ROS production (Garca-Ruiz et al., 1997)

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This has led to the false assumption that the cause of glutathione (GSH) depletion associated with so many chronic diseases must be from an under supply of cysteine in the diet

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