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The 180-day exclusivity prize is also lost for first-filers that lose litigation, as that exclusivity requires actual commercial marketing, which cannot occur while the adverse court ruling prevents approval

Keep in mind, while the logic of the methylation cycle and MTHFR variants suggests a preference for methylcobalamin, do consider other factors

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They come from vendor product pages and forum threads (LongeCity and similar), which is why this guide frames them as reported rather than recommended