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406,407 Interestingly, IDH1 mutants compete for NADPH to synthesize 2-HG with other pathways that are critical for cell viability, resulting in further disruption of cellular metabolism and redox homeostasis in tumorigenesis

Myelination refers to the process in which nerves acquire a myelin sheath the insulating layer of tissue made up of lipids and proteins that surrounds nerve fibers

The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization

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