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There is no chronic disease that exercise doesnt touch, says Robert Sallis, a clinical professor of family medicine in Fontana, California, and founder of Exercise Is Medicine

Patients should inform their healthcare providers about any kidney disease, significant weight changes, or other medications they are taking, as these factors may influence both the therapeutic effects and elimination timeline of GLP-1 receptor agonists

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1 However, recent randomised controlled trials (RCTs) have demonstrated the efficacy of some GLP-1 RAs for weight reduction in adults even without diabetes, leading to semaglutide and liraglutide approval as adjuncts to a calorie-restricted diet and exercise for weight management.2, 3, 4 Tirzepatide, a newer dual receptor agonist, has also been demonstrated to induce greater weight reductions, 5 and has recently been approved for patients without diabetes in some countries