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Call NHS 111 or seek same-day medical advice from your GP or diabetes specialist if you experience: Widespread rash covering large areas of the body Severe itching that significantly affects daily activities or sleep Blistering, peeling skin, or painful lesions Rash accompanied by fever, joint pain, or feeling generally unwell These symptoms may indicate a hypersensitivity reaction or other serious adverse effect requiring prompt assessment

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Importantly, the GLP-1R-cholesterol binding sites identified here do not overlap with previously predicted cholesterol consensus motifs (CCM) (22) or Cholesterol Recognition Amino Acid Consensus (CRAC) motifs (52) identified for other GPCRs, confirming the theory that GPCRs lack predictable primary sequence consensus motifs for cholesterol binding (53, 54)

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