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Managing Side Effects During Tirzepatide Dose Escalation Gastrointestinal effectsincluding nausea, vomiting, and constipationare the most common side effects during tirzepatide titration, occurring in 2540% of patients but typically diminishing after 48 weeks of consistent dosing

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Mild fatigue during the first few weeks of semaglutide treatment is common and often temporary

If you have noticed a new dark patch in your mouth, or an existing pigmented spot that has been changing in size, shape, colour or surface, it is worth booking an assessment without delay so the right biopsy and specialist referral can be arranged

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