Hypothesis-generating approaches Hypothesis-generating interventions rely on mechanistic reasoning or preliminary preclinical/clinical data, requiring further validation in humans
As the disease advances, ferroptosis-induced release of damage-associated molecular patterns (DAMPs), exosomal transmission, and immune evasion mechanisms further amplify neuroinflammation and cell damage, establishing a cascade of intercellular pathological propagation that accelerates neurodegeneration
Mills S, Stanton C, Fitzgerald GF, Ross RP: Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
Ghusn W, Hurtado MD
48 h) as described previously [40]
Understand the flowability of powders across pharmaceuticals, chemicals, and advanced materials, while staying compliant with USP, Ph