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In adipose tissue, GIPR promotes lipid storage and reduces lipolysis, contributing to energy balance

Flanagan EW, Most J, Mey JT, Redman LM (2020) Calorie Restriction and Aging in Humans Annual Rev Nutrit 40:105133

The difference between those who maintain and those who regain comes down to preparation before stopping and support afterward

Atkuri KR, Manovani JJ, Herzenberg LA, Herzenberg LA

That valuation leaves less room for ambiguity

Novo Nordisk already has an oral version of semaglutide, the active ingredient in Ozempic and Wegovy, on the market in Rybelsus, which was first approved in 2019, but that is indicated for treating Type 2 diabetes, not obesity