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Omar M E Abdel-Salam, et al

Adding in glucagon receptor agonist activity A clinically advanced molecule possessing glucagon receptor activity is the triple co-agonist retatrutide a single peptide molecule combining GLP-1, GIP and glucagon RA activity, delivered subcutaneously once weekly

doi:10.18632/oncotarget.12925 69

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Molecular Architecture Designing Balanced Activity Across Three Receptors Designing a balanced triple-receptor agonist is substantially more constrained than designing a single-receptor or dual-receptor compound