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Abbreviations VTS: Vanishing testis syndrome SHs: Sex hormones DHT: Dihydrotestosterone SDS: Standard deviation score IGF-1: Insulin-like growth factor-1 GH: Growth-hormone IGFBPs: Insulin-like growth factor-binding proteins References Houk CP, Hughes IA, Ahmed SF, Lee PA

Br J Cancer 2002;86:1854-7

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H 2 O 2 induces hepatocyte premature senescence via the p53/progerin-dependent pathway To further delineate the molecular mechanism of oxidative stress-induced cell premature senescence, primary hepatocytes, isolated from normal rats, were cultured and stimulated with H 2 O 2 at the different doses (0, 10, 50, 100, 200 nM) for 24 h or at the dose (200 nM) from 0 to 24 h

You notice changes in blood sugar regulation