CAR-T cells are genetically engineered to express a chimeric receptor composed of an antibody against a tumor antigen (such as CD19), a cytoplasmic domain of the zeta chain of the T-cell receptor, and a costimulator domain 42,43
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(iv) increased accumulation or production of potentially toxic saturated very long chain fatty acids 153,157 (Fig
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10 nmol/kg dose: PBS/PBS, n = 7
However, safety requires acknowledging that both compounds affect metabolic rate and energy utilization, meaning combined use demands careful monitoring