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Description

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SLC7A5 acts as a mandatory exchanger to mediate the efflux of leucine and glutamine from the cell through mutual coupling with SLC1A5 [41]

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Impaired astrocyte function can result in decreased elimination of extracellular glutamate, leading to a reduced seizure threshold and an imbalance between neuronal excitation and inhibition (Bialer & White, 2010)

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