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consider extending in CKD stage 4-5 How Semaglutide Works and Why Kidney Function Matters Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the incretin hormone GLP-1, slowing gastric emptying, reducing appetite through hypothalamic signaling, and enhancing glucose-dependent insulin secretion [1]

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A recent preclinical study by Regmi et al

And what lessons from other therapeutic areas can be integrated here to go further than we might if we remained narrowly focused on metabolism alone? Much of todays innovation pipeline builds on combining GLP-1 with other gut hormones