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GLP-1 receptor activation slows gastric emptying, increases satiety, and improves glucose-dependent insulin secretion

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Ribero S, Stucci LS, Marra E, Marconcini R, Spagnolo F, Orgiano L, et al

In addition, semaglutides ability to slow gastric emptying prolongs the feeling of fullness after meals, which supports reduced calorie intake and helps patients feel satisfied with smaller portions

While not absolutely contraindicated, active intestinal inflammation combined with GLP-1's effects on motility may trigger flares or worsen existing symptoms