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432 Mitochondria can store calcium ions and act in concert with the endoplasmic reticulum and extracellular matrix to control the dynamic balance of calcium ion concentration in cells and regulate the cell cycle and apoptosis
Obesity, visceral fat and Crohns disease
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This slowing contributes to the appetite suppression that drives weight loss and the postprandial glucose-lowering effect, and it also drives most of the gastrointestinal side effect profile.[1],[2] A 2025 review in the Journal of Clinical Endocrinology & Metabolism summarizes the published evidence: GLP-1 receptor agonists impact gastric, intestinal, and gallbladder motility simultaneously, with effects on gastric fundus relaxation, antral contractility inhibition, increased pyloric tone, and reduced small intestinal motility.[3] The path from this mechanism to constipation is straightforward
Gut microbe-derived N-acyl serinol lipids shape host postprandial metabolic homeostasis
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