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It is, by most measures, one of the most extensively studied peptides in the anti-aging literature.

TH, SZ and SL also involved in funding acquisition

K.Cruz-GregorioA.Pedraza-ChaverriJ

A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

For those who eat meat and dairy and do not have an underlying issue preventing B12 absorption, this should not be a problem

Although the calorie contents of weight gainer supplements vary, its not uncommon for some to contain more than 1,000 calories per serving