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In NSCLC, recent reports suggest that human lung cancer cell growth can be inhibited by GPX4-related ferroptosis, a type of cell death characterized by lethal accumulation of lipid-based ROS 17,18
Glutathione is a potent antioxidant known to have detoxifying properties as well as promote healthy skin and prevent oxidative stress
Thymoquinone (TMQ) has strong anti-psoriatic efficacy, but its hydrophobicity, low water solubility, and light and pH sensitivity limit its transport to the target site
-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice
Interestingly, macrophage SR-BI has recently been shown to mediate efferocytosis (phagocytosis of dead cells) in the setting of atherosclerosis via a Src/Akt/Rac1 signaling pathway, reducing necrosis in lesions (185)
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