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When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

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They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding approximately 300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects

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