For oral contraceptive pills: Take your pill at a time of day when nausea is minimal (usually not within 2 hours of your Zepbound injection) If you vomit within 2 hours of taking the pill, treat it as a missed dose (follow package instructions for missed pills) If GI side effects are persistent, consider switching to a non-oral method (patch, ring, IUD, implant, injection) For non-oral contraceptives (patch, ring, IUD, implant, injection): No interaction concern These methods don't rely on GI absorption For barrier methods: No interaction The FDA label for Zepbound states: "Tirzepatide causes a delay in gastric emptying and may impact the absorption of concomitantly administered oral medications." This is a general statement about all oral medications, not specific to contraceptives
Reported side effects are rare and mild: Localized irritation or redness at injection site
Commun Chem 9 , 221 (2026)
Free Radical Res (2015) 49(9):108194
The ratio of GSH to GSSG is a critical indicator of cellular oxidative stress and serves as a key regulator of the intracellular redox environment
It is designed to bind GHRH receptors on pituitary somatotroph cells, prompting the body's own pituitary gland to release growth hormone (GH), which in turn raises downstream IGF-1 levels
