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LM609 reduced 25HC-induced production of TNF and IL-6 by 35% and 90%, respectively (Fig

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Matrix composition includes type II collagen (providing tensile strength), aggrecan proteoglycans (providing compressive resistance), and water (65-80% of tissue weight)

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This anion then quickly breaks a disulfide bond and leads to Cys 63 nucleophilically attacking the nearest sulfide unit in the GSSG molecule (promoted by His 467 ) thus creating a mixed disulfide bond (GS-Cys 58 ) and a GS - anion

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