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doi: 10.1196/annals.1447.049 47 HirotaKDuarteJHVeldhoenMHornsbyELiYCuaDJet al

Int J Radiat Oncol Biol Phys (1999) 44(5):102738

PLAIN ENGLISH Each KLOW compound targets a real biological process

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell, essential for mitochondrial energy production, DNA repair, and sirtuin activation

This change extends its half-life, allowing it to remain active in the bloodstream for longer periods of time

However, ferroptosis plays a key role in the pathogenesis of several CCVDs, and studies have shown that ferroptosis is closely related to AS, MI, HF, DCM, hypertension, and IS (Wu et al., 2021a)