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Staines, Donald R

Studies have found that administering Bifidobacterium to ALD mice reduces levels of ALT, AST, TNF, IL1, TBA, and MDA, indicating that Bifidobacterium can ameliorate inflammation in ALD mice [249, 250]

It directly heals intestinal lining, reduces inflammation, and protects against various GI insults

Think of it as both reducing the supply of fat reaching the liver and enhancing the liver ability to process and export fat it already contains

Whether this is clinically meaningful depends on the indication

Notably, mangiferin exhibits a unique dual mechanism, not only significantly elevating p-AMPK expression levels but also innovatively targeting NLRP3 inflammasome activation, achieving marked reduction in hepatic lipid deposition (Xiang et al., 2024