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Hives, wheezing, and difficulty breathing are all signs of severe allergic reactions that require immediate medical attention.

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In addition, lower levels of Vitamin B12 in the blood may also be associated with a reduced bone mass or propensity to develop osteoporosis

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Gout especially favors the bunion joint, known as the first metatarsophalangeal joint (at the base of the big toe), but the ankle, midfoot and knee are also common locations, as is the bursa that overlies the elbow