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The following table describes GLP-1 receptor agonists, their dosing frequency and key pharmacokinetic parameters: Cautions and Contraindications Adverse Effects Acute pancreatitis (rare) Injection site reactions Gastrointestinal disturbances (nausea, vomiting, diarrhoea dehydration and possible renal impairment) Increase in pancreatic enzymes: lipase and amylase (dulaglutide, tirzepatide and semaglutide) Cholecystitis and cholelithiasis Delayed gastric emptying (semaglutide, exenatide, dulaglutide, tirzepatide (diminishes over time)) Increased heart rate Diabetic retinopathy complications (semaglutide, particularly in insulin-treated patients with known diabetic retinopathy) Interactions GLP-1 receptor agonists do not interact via cytochrome P450 , but delayed gastric emptying may alter drug absorption
[DOI] [PubMed] [Google Scholar] 44.Daz-Vliz G, Paris I, Mora S, Raisman-Vozari R, Segura-Aguilar J
As you may already know, GLP-1s work by mimicking two hormones
A review indicated that some lean people and obese people have similar risk of cardiovascular complications due to differences in fat distribution (8)
Start with small portions and listen to your body
This is when the metabolic rebound is most intense, when appetite is most elevated, and when the habits you built during treatment are most vulnerable to erosion
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