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Stainless steel guide cannulas were bilaterally implanted into the DMV, the PVN or the other five brain regions following stereotaxic coordinates: the S1 coordinates: AP, 0.47 mm

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And TMAO could exacerbate oxidative stress through upregulation of NOX4 and downregulation of SOD

Experts attribute this difference to tirzepatide's dual-receptor mechanism, which influences not only appetite but also metabolic processes such as glucose regulation and fat utilization