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This unique transformation allows NAC to squelch free radicals directly at the site of ATP energy production, protecting the mitochondrial inner membrane from lipid peroxidation

Halim TY, Krauss RH, Sun AC, Takei F

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ROXY9 is oxidized to ROXY9-S 2 depending on the redox potential of the GSH/GSSG couple, while class I GRXs adopt a stable equilibrium between the glutathionylated and the S 2 -containing state over a wide range of redox potentials established by GSH/GSSG