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interleukin (IL)-1 and IL-6)

Indications: Provides antioxidants that help protect against the oxidative damage caused by free radicals

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Titrate (Weeks 34): Increase to 40 mcg daily if Week 12 well-tolerated with no significant hypoglycemic symptoms

It is engineered with two structural modifications relative to the 70-residue native protein: a substitution of arginine for glutamic acid at the third position and a 13-amino-acid extension at the N-terminus, giving a total length of 83 amino acids

For example, autophagy inhibitors may be paired with chemotherapies or checkpoint inhibitors in cancers with elevated autophagy, whereas activators may be combined with metabolic regulators in neurodegenerative disorders