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10.1016/j.cmet.2013.02.004 2
Cell culture studies have shown that NNMT inhibition increases intracellular NAD+ levels, enhances sirtuin activity, and shifts adipocyte metabolism toward greater fatty acid oxidation
Protect the heart Some GLP-1 medications lower the risk of cardiovascular events in people with diabetes
However, GLP-1 can act as a helpful addition especially for patients who: Have obesity or are overweight Have type 2 diabetes or metabolic syndrome Need improvements in multiple metabolic risk factors (not just cholesterol) Who Benefits Most The cholesterol and lipid benefits of GLP-1 tend to be greater in: People who lose significant weight on it Those with elevated triglycerides to start Patients with insulin resistance or type 2 diabetes Individuals implementing lifestyle changes (diet, physical activity, etc.) alongside medication What to Expect & Important Things to Know Timeframe : Changes in lipid levels usually show up over months not immediately
