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Sitagliptin, a dipeptidyl peptidase-4 inhibitor, ameliorate ERS in both albumin-treated PETCs and the kidneys of diabetic DBA2/J (D2) mice through upregulation of SIRT1 (85)

Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease

[47] Peptide-based Therapy against Pro-inflammatory Cytokines/Chemokines Since pro-inflammatory cytokines and chemokines play a critical role in the pathogenesis of many autoimmune diseases, peptide-based vaccines have been designed to antagonize the pro-pathogenic cytokines and chemokines to reduce inflammation and tissue damage

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The doses were representative of the average MTX IC50 (96 hours) across all cell lines (18.4 nM)