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The most common PT-141 side effects include (9): flushing/redness headaches nausea/vomiting irritation at the injection site Rare side effects include: blurred vision dizziness pounding in the ears focal skin hyperpigmentation People with cardiac disease or uncontrolled hypertension should avoid taking PT-141, Staheli says, because it may increase blood pressure

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On the other hand, strenuous and/or damaging exercise elicits a stress response analogous to the acute-phase immune response

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For example, nausea affects up to 44% of patients on the highest dose of semaglutide (Wegovy), though rates are typically lower at starting doses