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Regardless of its origin, vitamin D undergoes two steps: first, in the liver, it is hydroxylated by 25-hydroxylase (CYP2R1) to form 25-hydroxyvitamin D [25(OH)D], and subsequently, in the kidney, it is hydroxylated by 1-hydroxylase (CYP27B1) to generate the biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)D] ( 1,25(OH)D exerts its effects by binding to the nuclear vitamin D receptor (VDR), forming a heterodimer with the retinoid X receptor (RXR), which then binds to vitamin D response elements (VDREs) on target genes
doi: 10.1007/s10142-014-0427-7 2 AlbertN
Best practices for combination use : Take vitamin C supplements 30 minutes before glutathione for optimal absorption The typical ratio is 1000mg vitamin C with 500mg glutathione For topical use, apply vitamin C serum in the morning and consider oral glutathione supplementation Always use sunscreen, as both ingredients can increase photosensitivity Which Form Should You Choose
