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When cortisol/11-deoxycortisol ratio and GPx were added conjointly in the model, the significant association with cortisol/11-deoxycortisol was lost, whereas important clusters remained significant with GPx, suggesting that GPx activity mediated the association between cortisol/11-deoxycortisol ratio and gFA

Pathway analysis revealed targets associated with chromatin regulation, cortisol synthesis, steroid metabolism and glutamate metabolic processes ( 5e )

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Larger clinical trial studies are needed before these medications are prescribed for individuals who have an addiction