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Discussion Mounting evidence implicates that obesity represents a state of long-term, low-grade inflammation, and ATMs are a significant contributor to systematic inflammation and dysfunctional insulin action in obese individuals [51]

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10.1002/adma.201802244 74 XiongY.-X.XiaoC.LiZ.-F.YangX.-L

This binding may open ion channels, activate second messengers such as cyclic AMP, or initiate kinase cascades that alter gene expression and enzyme activity

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