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Semaglutide is a GLP-1 medication that reduces appetite, slows stomach emptying, and helps control blood sugar levels, making it easier to achieve and maintain a healthy weight

The patients eventual relapse upon restarting Ozempic proves the drug is the pathological driver, perpetually compromising the VNC and preventing therapeutic gain

doi: 10.1074/jbc.M804372200 31 FourtnerSHStanleyCAKellyA

MiR-370 targets CPT1A reducing FAO

Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023

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