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Kisspeptin daily (hormonal base, HPG axis stimulation) plus PT-141 as-needed (acute MC4R-mediated desire boost)

The methionine loading results in an abnormal increase in homocysteinemia, revealing a defect in the transsulfuration pathway, which is attenuated by folic acid and/or pyridoxine supplementation

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To evaluate the safety of GLP-1-RAs in various patient groups and to determine the best way to use them to treat T2DM, it is critical to continue monitoring their effects and conducting long-term studies

Adding GOLO, which lacks comparable evidence, is unlikely to enhance results and may complicate the assessment of treatment response

Since the short-acting GLP-1RAs are more rapidly cleared from plasma, GLP-1 receptor activation is also short-lived