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In this study, we used cryogenic electron microscopy (cryo-EM) to determine structures of Cagri bound to Gs-coupled, active, AMY 1 R, AMY 2 R, AMY 3 R and CTR and compared the mode of interaction of Cagri and the associated dynamics of the Cagri-bound receptor complexes with previously reported cryo-EM structures and dynamics of receptors bound to rat amylin (rAmy, all receptor subtypes), sCT (CTR, AMY 1 R, AMY 2 R) 15 or recently developed amylin-based peptides (CTR and/or AMY 3 R) 16

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The next day, the suspensions were centrifuged at 8,500 g for 5 min at 4C, and the supernatants were removed

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Even with the oral administration of an extremely high dose (3 g) of glutathione, it was not possible to achieve any changes in the amount of the substance circulating in the blood