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Thats what Holst really wanted me to know after his decades of work on the topic

After penetrating the skin, the cream enters the systemic circulation and combines with relevant receptors across the blood-brain barrier, promoting the release of dopamine and norepinephrine

Findings from the pivotal New England Journal of Medicine trial confirmed a 4.3% reduction in BMI over 56 weeks, supporting its clinical effectiveness in this age group

Tirzepatide also reduced BMI and waist circumference

Most evidence comes from secondary analyses of diabetes and obesity trials where joint symptoms were not primary endpoints

Expert Opin Biol Ther 24(11):12071219