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These effects were less pronounced in male SKO mice, although beneficial effects were still observed on hepatomegaly and fibrosis

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Stopping the medication often leads to regaining lost weight unless lifestyle changes like diet and exercise are consistently maintained

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doi: 10.1016/j.neuint.2019.04.010 89 SmithP

Many community references include 2-4 week off-periods between cycles to allow fresh evaluation, although the rationale is community-derived rather than trial-validated