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8 , e2696 (2017)
Symptoms often include discomfort in the liver area, while complications such as sarcopenia, hepatic encephalopathy, ascites, upper gastrointestinal bleeding, and infection can arise
For example, GLP-1R/GIPR dual agonists seem preferential in treatment of modestly overweight individuals with diabetes, where the emphasis is on metabolic control with lesser requirement for body weight reduction
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Similarly, metabolites such as ferredoxic acid and 2-hydroxyglutaric acid can affect DNA demethylation enzymes (201), thus favoring chromatin condensation and preventing transcription factor binding and gene silencing (202, 203)
6,7 However, large-scale studies evaluating the combined effects of T2DM and CVRFs have not yet been conducted
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