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In metabolic dysfunction-related steatohepatitis (MASH), preclinical models show GLP-1s reduced hepatic inflammation, lipid accumulation, and fibrosis-related markers

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Some Aetna insurance plans may cover GLP-1 medications like Wegovy or Zepbound for obesity

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It also appears to stimulate the bodys natural GLP-1 production, the same gut hormone activated by semaglutide

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Many insurance plans require prior authorization before they will cover weight loss medications

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It will be important to determine the roles of GLP-1 agonisms as compared to SGLT2i in this patient population

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Journal of Medicinal Chemistry

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