The mechanisms of action all combine so that you take in fewer calories and make more out of them energetically while making less out of them as fat
This mechanism protects against dangerous blood sugar drops that occur with some older diabetes medications
Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node, Cardiovascular Research (2024) Semaglutide and cardiovascular outcomes in obesity without diabetes, The New England Journal of Medicine (2023) Real-world safety profile of once-weekly semaglutide in people with type 2 diabetes: Analysis of pooled data from the SemaglUtide Real-world Evidence (SURE) programme, Diabetes, Obesity and Metabolism (2024) Ozempic (semaglutide injection) product monograph (2018) Tachycardia, Mayo Clinic (2023) How to check your heart rate (manually and using a device), Mass General Brigham (2025) Target Heart Rates Chart, American Heart Association (2025) Craig D
As your dose gradually increases in line with prescribing guidelines, semaglutide continues to influence appetite
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By reducing food intake and lowering blood sugar, semaglutide encourages gradual weight loss
